Xeomin 100 IU Injection (Clostridium Botulinum Neurotoxin Type A)

What is Xeomin 100 IU Injection (xeomin aesthetics)

Xeomin 100 IU Injection (Clostridium Botulinum Neurotoxin Type A) is a prescription botulinum toxin medicine containing incobotulinumtoxinA. It is given by a qualified healthcare professional into selected muscles or salivary glands, depending on the condition being treated.

Xeomin works by reducing signals between nerves and targeted muscles or glands. This can temporarily reduce unwanted muscle activity or decrease excess saliva production. It is used for several medical conditions and also for the temporary improvement of certain facial lines in adults.

The U.S. prescribing information measures Xeomin in Units. Although the product may sometimes be described as Xeomin 100 IU, Xeomin Units are specific to this medicine and should not be compared with, or converted directly to, Units of Botox, Dysport, Daxxify, Jeuveau, or other botulinum toxin products.

What Is Xeomin 100 Units Injection Used For?

Xeomin has both therapeutic and cosmetic uses. The exact treatment plan depends on the patient’s condition, age, symptoms, medical history, and the area being treated.

Approved uses include:

• Chronic sialorrhea: Xeomin may be used for long-lasting excessive drooling in adults and children 2 years of age and older.
• Upper limb spasticity: It may reduce increased muscle stiffness in the arms in adults and children 2 years of age and older.
• Cervical dystonia: In adults, Xeomin may help manage abnormal neck muscle contractions that can cause unusual head position and neck pain.
• Blepharospasm: It may be used to treat involuntary eyelid muscle spasms in adults.
• Upper facial lines: In adults, Xeomin can temporarily improve moderate-to-severe frown lines between the eyebrows, horizontal forehead lines, and lateral canthal lines (commonly called crow’s feet).

How Does Xeomin Injection Work?

IncobotulinumtoxinA reduces the release of acetylcholine, a chemical that nerves use to activate muscles and certain glands.

When Xeomin is injected into a selected muscle, it temporarily reduces the nerve signal that tells that muscle to contract. This can help decrease excessive or unwanted muscle activity.

When injected into the salivary glands to treat chronic sialorrhea, it can reduce saliva production.

The effect is temporary. The prescribing information reports a median onset of effect within about 2 to 7 days after treatment, with a typical treatment effect lasting up to about 12 to 16 weeks. The actual response and duration can vary from person to person.

Xeomin 100 Units Dosage and Administration

Xeomin is not intended for self-injection. A trained healthcare professional determines the appropriate dose, treatment area, number of injection sites, and timing of repeat treatment.

The amount needed can vary widely depending on whether Xeomin is used for upper-limb spasticity, cervical dystonia, blepharospasm, chronic sialorrhea, or facial lines.

Previous treatment with another botulinum toxin may also affect the clinician’s treatment plan. The dose of another botulinum toxin product should not simply be converted to Xeomin Units, as potency measurements are product-specific.

Available Xeomin Strengths

Xeomin is available as a sterile powder in single-dose vials that must be prepared correctly before administration.

Available U.S. vial strengths include:

• Xeomin 50 Units
• Xeomin 100 Units
• Xeomin 200 Units

Possible Side Effects of Xeomin

Side effects can vary depending on why Xeomin is being used and where it is injected. Reported reactions can include injection-site pain or bruising, dry mouth, muscle weakness, neck pain, dry eye, eyelid drooping, visual problems, or difficulty swallowing.

Not every patient experiences the same side effects. Some effects may also be related to the specific muscles or glands being treated.

Tell the healthcare professional about any previous reactions to botulinum toxin products and any medical conditions affecting the muscles, nerves, swallowing, or breathing.

Important Xeomin Safety Warning

Xeomin and other botulinum toxin products carry a boxed warning about the possible spread of toxin effects beyond the injection area.

Symptoms may develop hours to weeks after treatment and can include general muscle weakness, double or blurred vision, drooping eyelids, changes in voice, difficulty speaking, trouble swallowing, or breathing problems. Swallowing and breathing problems can be life-threatening.

Urgent medical care is needed if breathing, swallowing, or speech problems occur after treatment.

Xeomin should not be given to someone with a known hypersensitivity to botulinum toxin or its ingredients. It is also contraindicated when there is an infection at the planned injection site.

Medicines and Health Conditions to Discuss Before Treatment

Before receiving Xeomin, patients should give their healthcare provider an up-to-date list of prescription medicines, over-the-counter products, and recent botulinum toxin treatments.

Extra care may be needed with certain antibiotics, such as aminoglycosides, muscle relaxants, anticholinergic medicines, and drugs that affect communication between nerves and muscles.

People with existing swallowing or breathing problems, or with disorders affecting nerves and muscles, may be at higher risk of significant adverse effects. Pregnancy and breastfeeding should also be discussed with a healthcare professional before treatment.

Xeomin Substitutes and Other Botulinum Toxin Options

Several other botulinum toxin medicines are available, but they are not direct dose-for-dose substitutes for Xeomin. Each product has its own formulation, potency measurement, approved uses, dosing recommendations, and safety information.

Common options include:

• Botox / Botox Cosmetic (onabotulinumtoxinA): Used for a range of medical and cosmetic conditions, depending on the specific product and indication.
• Dysport (abobotulinumtoxinA): Approved for conditions including spasticity, cervical dystonia, and temporary improvement of glabellar lines in eligible patients.
• Daxxify (daxibotulinumtoxinA-lanm): Approved for adult cervical dystonia and temporary improvement of moderate to severe glabellar lines.
• Jeuveau (prabotulinumtoxinA-xvfs): Approved for temporary improvement of moderate to severe glabellar lines in adults.
• Myobloc (rimabotulinumtoxin B): A botulinum toxin type B product used for adult cervical dystonia and chronic sialorrhea.

FAQs About Xeomin 100 IU Injection

1. Does unopened Xeomin need to be kept in a refrigerator?

2. How long can Xeomin be kept after it has been reconstituted?

3. What other ingredients are found in Xeomin?

4. Is the Xeomin vial closure made with natural rubber latex?

5. Does Xeomin contain accessory or complexing proteins?