Crinone Vaginal Gel 1.125 g (Progesterone)

Introduction About Crinone Vaginal Gel 1.125 g (Progesterone)

Crinone Vaginal Gel 1.125 g (Progesterone) is a prescription vaginal progesterone used to support the uterine lining when your body lacks progesterone, including in fertility treatment.

Each prefilled applicator provides local medication, typically once daily. It may help regulate cycles in progesterone deficiency. Use only as directed by your clinician. Ask about side effects and monitoring.

What Crinone Vaginal Gel is

Crinone is a vaginal progesterone gel in a prefilled applicator for local absorption. It is straightforward to use and fits into many fertility schedules.

You may see it described online using search terms like:

• progesterone vaginal gel 8%
• Crinone progesterone gel 1.125 g
• progesterone gel for IVF support
• luteal phase support medication
• Progesterone supplementation for fertility treatment

What it’s commonly prescribed for

Clinicians prescribe Crinone for a few well-known situations, including:

• Crinone is prescribed to support the uterine lining during assisted reproductive technology (ART), such as IVF protocols, and to address progesterone deficiency that may cause missed periods. Your use, dose, and duration will depend on your specific situation.
• Progesterone replacement in certain cycle-related conditions, such as progesterone deficiency that can contribute to missed periods (your prescriber will decide if this applies to you)

Your exact reason for use matters because it can affect dose, schedule, and duration.

How it’s typically used (high level)

Crinone is used vaginally, not orally. Most plans use one prefilled applicator daily; some protocols may require twice-daily dosing. Timing and duration are individualised based on your fertility clinic’s guidance and monitoring.

If unsure about usage, ask a pharmacist or nurse for guidance. Small technique mistakes can make the process messier or more uncomfortable.

What you might notice while using Crinone

Crinone’s gel form may cause vaginal discomfort, irritation, a feeling of fullness, increased vaginal discharge, or mild cramping. Systemic effects such as headache, breast tenderness, bloating, fatigue, and mood changes are also possible.

• a feeling of fullness
• increased vaginal discharge
• mild cramping

Systemic (whole-body) progesterone effects can also happen, such as:

• headache
• breast tenderness
• bloating
• sleepiness or fatigue
• mood changes

Seek urgent care for symptoms like chest pain, shortness of breath, severe headache, sudden vision changes, or leg swelling and pain. These are rare but serious.

Important safety notes to know upfront

Crinone is not right for everyone. Make sure your prescriber knows if you have a history of, or current concerns with:

• unexplained vaginal bleeding
• blood clots, stroke, or clotting disorders
• liver disease
• certain hormone-sensitive cancers (such as breast cancer)
• allergies to progesterone or any ingredient in the product

Share your full medical history, including migraines, depression, or high blood pressure, as hormonal medications can affect these conditions.

Available strengths (other dosages you may see)

Crinone is available in different strengths. The most common marketed options include:

• Crinone 8% vaginal gel: typically delivers 90 mg progesterone per 1.125 g applicator
• Crinone 4% vaginal gel: typically delivers 45 mg progesterone per 1.125 g applicator

Your prescription will specify the strength and how often to use it. These strengths are not interchangeable without prescriber guidance.

Substitute options already in the market

If Crinone is unavailable or unsuitable, your clinician may recommend other progesterone forms. These are not direct swaps; dosing and absorption may vary.

• Endometrin (progesterone vaginal insert, often 100 mg)
• Prometrium (micronised progesterone oral capsule, sometimes used vaginally in certain protocols based on prescriber direction)
• Progesterone in oil intramuscular injections (commonly used in some IVF protocols)
• Compounded progesterone vaginal suppositories (availability and consistency can vary by pharmacy)

If switching forms, confirm your plan in writing, especially during time-sensitive fertility cycles.

FAQs

1. Is it normal to see white residue or clumps after using Crinone?

Leftover white or paste-like gel can occur. If you have a strong odour, itching, fever, or pain, contact your clinician to check for infection.

2. Can I use tampons while using Crinone vaginal gel?

Ask your prescriber. Tampons may absorb medication and lower the dose. Many clinics advise avoiding tampons during vaginal progesterone use.

3. Can I have sex after applying Crinone?

Some clinics suggest waiting after dosing before sex to reduce mess and avoid disrupting absorption. Follow your clinic’s guidance.

4. Will Crinone affect a Pap smear or a vaginal exam?

Crinone may leave residue that complicates exams. Tell your provider if you’re using vaginal progesterone before a scheduled exam.

5. Does Crinone need refrigeration, and what if I’m travelling?

Storage depends on product labelling and pharmacy instructions, but most are stored at room temperature, away from heat. When travelling, keep it in a temperature-stable place and check your package instructions.