Alprostadil Injection 500 mcg (Prostacel)

About Alprostadil Injection 500 mcg (Prostacel)

What Alprostadil does

In ductal-dependent congenital heart disease, a newborn may need the ductus arteriosus (a normal fetal blood vessel) to remain open to maintain adequate blood flow and oxygen delivery until definitive treatment is available.

Alprostadil relaxes smooth muscle and promotes vasodilation, helping keep the vessel open temporarily. This can support circulation while the medical team prepares for transfer, imaging, catheter-based procedures, or surgery, depending on the diagnosis.

How is it given

This product is generally administered by IV infusion after dilution, using an infusion pump to control the dose very precisely. The exact protocol varies by hospital, the baby’s condition, and the baby’s response.

Clinicians often begin with a dose that can be adjusted up or down based on oxygenation and perfusion goals, side effects, and monitoring results. If you are a caregiver, the key thing to know is that dosing is not “one size fits all” and is always directed by the treating team.

Monitoring matters with this medication

Side effects and safety notes

Side effects depend on the patient and the dose. Possible effects can include flushing, fever, low blood pressure, fast or slow heart rate, and breathing changes. More serious reactions are uncommon but can happen, which is why continuous monitoring is standard.

Tell the clinical team about any known allergies, unusual reactions to prostaglandins, or any other medicines the patient is receiving. In neonatal care, providers also consider fluid status and overall cardiopulmonary stability during therapy.

Drug compatibility and interactions

With IV medicines, compatibility can matter as much as the medication itself. Alprostadil is usually run through controlled IV lines, and the team will decide on dilution fluids, tubing, and whether it can share a line with other infusions.

If you are coordinating care or supplies, do not assume IV compatibility without confirmation from a pharmacist or the hospital’s protocol.

Storage and handling

Alprostadil products are commonly stored refrigerated and protected from light, but storage directions can vary by manufacturer and packaging. Always follow the label on the carton/ampule.

Do not use an ampule if the solution looks discolored, cloudy, or has particles (unless the manufacturer’s labeling clearly indicates otherwise). For clinical settings, proper cold chain handling is important.

Available strengths

• Prostacel 500mcg Injection (Alprostadil)
• Alprostadil injection kits for erectile dysfunction (typically much smaller doses such as 10 mcg, 20 mcg, 40 mcg per vial/kit, depending on brand).
• Intraurethral alprostadil (often 125 mcg, 250 mcg, 500 mcg, 1000 mcg), which is a different dosage form and use case.

Substitutes and market alternatives

• Generic alprostadil injection (same active ingredient, different manufacturer)
• Prostin VR Pediatric (well-known alprostadil brand associated with neonatal ductal patency use)
• For erectile dysfunction use (different dosing and product design): Caverject, Edex, and MUSE (all alprostadil-based, but not interchangeable with infusion products)

FAQs